Research Paper Volume 12, Issue 1 pp 260—287
CircNF1-419 improves the gut microbiome structure and function in AD-like mice
- 1 State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China
- 2 Guangdong Pharmaceutical University, Guangzhou 510006, China
- 3 Guangxi University of Chinese Medicine, Nanning 530023, China
- 4 Academy of Life Sciences, Jinan University, Guangdong Province, Guangzhou 510000, China
- 5 Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China
- 6 Department of Physiology, Shantou University Medical College, Shantou 515063, China
received: August 12, 2019 ; accepted: December 5, 2019 ; published: January 6, 2020 ;https://doi.org/10.18632/aging.102614
How to Cite
Copyright © 2020 Diling et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Our pre-experiments found that the brain circRNA sequence profiles and gut microbiota in AD-like mice were changed, as circNF1-419 could enhance autophagy to ameliorate senile dementia in AD-like mice, so we conclude that there might some connections between circRNA and gut microbiome. Therefore, we use the over-expressed circNF1-419 adeno-associated virus (AAV) animal system with the aim of identifying possible connections. Our results showed that over-expression of circNF1-419 in brain not only influenced the cholinergic system of brain, but also changed the gut microbiota composition as the Candidatus Arthromitus, Lachnospiraceae FCS020 group, Lachnospiraceae UCG-006, and [Eubacterium] xylanophilum group, and the intestinal homeostasis and physiology, and even the gut microbiota trajectory in new born mice. These findings demonstrate a link between circRNA and gut microbiome, enlarge the ‘microbiome- transcriptome’ linkage library and provide more information on gut-brain axis.