Research Paper Volume 12, Issue 1 pp 884—893
Pineal gland volume is associated with prevalent and incident isolated rapid eye movement sleep behavior disorder
- 1 Department of Brain and Cognitive Science, Seoul National University College of Natural Sciences, Seoul, Korea
- 2 Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, Korea
- 3 Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea
- 4 Department of Radiology, Seoul National University College of Medicine, Seoul, Korea
- 5 Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea
received: September 11, 2019 ; accepted: December 24, 2019 ; published: January 9, 2020 ;https://doi.org/10.18632/aging.102661
How to Cite
Copyright © 2020 Park et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
We aimed to investigate the association of pineal gland volume with the risk of isolated rapid eye movement (REM) sleep behavior disorder (RBD). We enrolled 245 community-dwelling cognitively normal elderly individuals without major psychiatric or neurological disorders at the baseline evaluation, of whom 146 completed the 2-year follow-up evaluation. We assessed RBD symptoms using the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ) and defined probable RBD (pRBD) as an RBDSQ score of ≥ 5. We manually segmented the pineal gland on 3T T1-weighted brain magnetic resonance imaging and estimated its volume. The smaller the baseline pineal gland volume, the more severe the RBD symptoms at baseline. The individuals with isolated pRBD showed smaller pineal gland volumes than those without isolated pRBD. The larger the baseline pineal gland volume, the lower the risks of prevalent isolated pRBD at the baseline evaluation and incident isolated pRBD at the 2-year follow-up evaluation. Pineal gland volume showed good diagnostic accuracy for prevalent isolated pRBD and predictive accuracy for incident isolated pRBD in the receiver operator characteristic analysis. Our findings suggest that pineal gland volume may be associated with the severity of RBD symptoms and the risk of isolated RBD in cognitively normal elderly individuals.