Research Paper Volume 12, Issue 3 pp 2545—2583

Global burden of larynx cancer, 1990-2017: estimates from the global burden of disease 2017 study

Yujiao Deng1,2, *, , Meng Wang1,2, *, , Linghui Zhou1,2, *, , Yi Zheng1,2, , Na Li1,2, , Tian Tian2, , Zhen Zhai1,2, , Si Yang1,2, , Qian Hao2, , Ying Wu1,2, , Dingli Song2, , Dai Zhang2, , Jun Lyu3, , Zhijun Dai1,2, ,

  • 1 Department of Breast Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
  • 2 Department of Oncology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710004, China
  • 3 Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou 510632, China
* Equal contribution

Received: August 30, 2019       Accepted: January 12, 2020       Published: February 8, 2020
How to Cite

Copyright: © 2020 Deng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Larynx cancer is one of the most common cancers in head and neck. This study aimed to investigate the health burden of larynx cancer at global, regional, and national levels. We collected data of larynx cancer between 1990 and 2017 from the Global Burden of Disease study, including incidence, mortality, and disability adjusted life-years (DALYs). Estimated annual percentage changes (EAPCs) were calculated to assess the changes in age-standardized rate (ASR) of larynx cancer. From 1990 to 2017, LC incident cases increased by 58.67%; however, age-standardized incidence rate (ASIR) decreased, with an EAPC of -0.99. Additionally, the incident cases and ASIR of LC were 6-fold higher for male than those for female in 2017. Over the past 28 years, deaths and DALYs of larynx cancer increased by 33.84% and 25%. Contrarily, age-standardized death and DALY rate showed a downward trend. Incidence, death, and DALYs of larynx cancer were always the highest in people aged 50-69 years. Overall, all the ASRs showed downward trends globally. The majority of larynx cancer burden was observed in men, especially among male aged 50-69 years. South and East Asia carried the heaviest burden of larynx cancer worldwide.


ASDR: Age-standardized death rate; ASIR: Age-standardized incidence rate; ASR: Age-standardized rate; DALY: Disability adjusted life-years; EAPC: Estimated annual percentage changes; GBD: Global Burden of Disease; LC: Larynx cancer; SDI: Socio-demographic index; HPV: Human papillomavirus.