Research Paper Volume 12, Issue 6 pp 4907—4917

The neurocognitive and BDNF changes of multicomponent exercise for community-dwelling older adults with mild cognitive impairment or dementia: a systematic review and meta-analysis

Xinyi Wang1, , Haiyun Wang1, , Zhenghui Ye1, , Guofei Ding1, , Fengli Li1, , Ji Ma1, , Wei Hua1, ,

  • 1 Department of Anesthesiology, Tianjin Third Central Hospital, Nankai University Affinity the Third Central Hospital, The Third Central Clinical College of Tianjin Medical University, Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin 300170, China

Received: November 16, 2019       Accepted: March 3, 2020       Published: March 19, 2020
How to Cite

Copyright © 2020 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Our goal was to examine whether multicomponent exercise performed by older adults with mild cognitive impairment or dementia as group-based exercise in community have beneficial effects on cognition and brain-derived neurotrophic factor. Eight studies were identified through Emabase, Medline, PubMed. Searches combined terms for neurocognitive and biochemical changes with those for MCI and dementia. Data were extracted and checked by a second reviewer, systematically reviewed, and meta analyzed where appropriate. There was significant difference in favor of multicomponent exercise in cognition (WMD:0.18; 95%CI:0.02-0.34), attention (SMD=2.16; 95%CI:1.2to3.12) and executive function (SMD =0.80; 95%CI: 0.28to1.31), but not in memory. However, there was limited reporting of the effects of multicomponent exercise on depression and brain-derived neurotrophic factor for this group of people. In conclusion, this meta-analysis indicated that group exercises improve cognition, attention and executive function in community-dwelling older adults with mild cognitive impairment or Alzheimer's disease.


AD: Alzheimer’s Disease; ADAS: Alzheimer’s Disease Assessment Scale; CDR: Clinical Dementia Rating; CDT: Clock Drawing Test; CWM: Composite Word Memory; DRS: Dementia Rating Scale; DSC: Digit Symbol Coding; DST: Digit Span Test; GDS: Geriatric Depression Scale-15; L/CVF: Letter/Categorical Verbal Fluency; MCI: Mild Cognitive Impairment; MMSE: Mini-Mental State Examination; MoCA: Montreal Cognitive Assessment; SCWT: Stroop Color Word test; SDST: Symbol Digit Substitution Test; SWM: Spatial Working Memory; TMT: Trail Making Test; VFT: Verbal Fluency Test; WMS-LM: Logical Memory Subtest of the Wechsler memory scale-revised.