COVID-19Research Paper|Volume 12, Issue 7|pp 6037—6048

Predictors for imaging progression on chest CT from coronavirus disease 2019 (COVID-19) patients

Zongguo Yang¹, Jia Shi¹, Zhang He², Ying Lü¹, Qingnian Xu¹, Chen Ye¹, Shishi Chen¹, Bozong Tang¹, Keshan Yin¹, Yunfei Lu¹, Xiaorong Chen¹

¹Department of Integrative Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China
²Department of Neurology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China

* Equal contribution

Received: February 29, 2020Accepted: March 28, 2020Published: April 10, 2020

https://doi.org/10.18632/aging.102999

Copyright © 2020 Yang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: This study aimed to investigate the potential parameters associated with imaging progression on chest CT from coronavirus disease 19 (COVID-19) patients.

Results: The average age of 273 COVID-19 patients enrolled with imaging progression were older than those without imaging progression (p = 0.006). The white blood cells, platelets, neutrophils and acid glycoprotein were all decreased in imaging progression patients (all p < 0.05), and monocytes were increased (p = 0.025). The parameters including homocysteine, urea, creatinine and serum cystatin C were significantly higher in imaging progression patients (all p < 0.05), while eGFR decreased (p < 0.001). Monocyte-lymphocyte ratio (MLR) was significantly higher in imaging progression patients compared to that in imaging progression-free ones (p < 0.001). Logistic models revealed that age, MLR, homocysteine and period from onset to admission were factors for predicting imaging progression on chest CT at first week from COVID-19 patients (all p < 0.05).

Conclusion: Age, MLR, homocysteine and period from onset to admission could predict imaging progression on chest CT from COVID-19 patients.

Methods: The primary outcome was imaging progression on chest CT. Baseline parameters were collected at the first day of admission. Imaging manifestations on chest CT were followed-up at (6±1) days.