Research Paper Volume 12, Issue 19 pp 19221—19232

Association of physical activity with chronic kidney disease: a systematic review and dose-response meta-analysis

Yongjian Zhu1, , Yongjun Bu1, , Guofu Zhang1, , Shibin Ding1, , Desheng Zhai1, , Zhongxiao Wan2, , Zengli Yu1,2, ,

  • 1 School of Public Health, Xinxiang Medical University, Xinxiang 453003, China
  • 2 School of Public Health, Zhengzhou University, Zhengzhou 450001, China

Received: May 22, 2020       Accepted: July 7, 2020       Published: October 7, 2020
How to Cite

Copyright: © 2020 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: The relationship between physical activity (PA) and chronic kidney disease (CKD) risk was inconsistent. We therefore conducted a systematic review and dose-response meta-analysis to comprehensively evaluate the association of PA and CKD.

Results: A total of 14 studies from 13 articles with 353,975 participants were included. By comparing the highest vs. the lowest level of PA, we found that PA was inversely associated with CKD risk (odds ratio [OR] = 0.94, 95% confidence interval [CI] = 0.91–0.98). Seven studies from 6 articles were included in dose–response analysis. Restricted cubic splines showed no evidence of a nonlinear dose–response relationship of PA and CKD risk (Pnonlinearity = 0.135). The risk of CKD was reduced by 2% (OR = 0.98, 95% CI = 0.96–1.00) with each 10 metabolic equivalent h/week increment of PA.

Conclusions: The findings demonstrated that the higher level of PA might have a protective effect against the risk of CKD.

Methods: Electronic databases PubMed and Embase were searched up to March 11, 2020. Observational studies investigated the relationship between PA and CKD risk with estimated effects (relative risk, hazard ratio, or OR) with 95 % CI among adults were included.


CKD: chronic kidney disease; PA: physical activity; WHO: world health organization; NCDs: non-communicable diseases; OR: odds ratio; CI: confidence interval; MET: metabolic equivalent; BMI: body mass index; LTPA: leisure time physical activity; RR: relative risk; HR: hazard ratio.