Research Paper Volume 12, Issue 19 pp 19539—19545
Complex interplay among fat, lean tissue, bone mineral density and bone turnover markers in older men
- 1 Department of Medical Rehabilitation and Clinical Physiotherapy, Pomeranian Medical University in Szczecin, Szczecin, Poland
- 2 Department of Orthopaedics Traumatology and Musculoskeletal Oncology, Pomeranian Medical University in Szczecin, Szczecin, Poland
- 3 Department of Propedeutics of Internal Medicine and Arterial Hypertension, Pomeranian Medical University in Szczecin, Szczecin, Poland
Received: April 24, 2020 Accepted: July 30, 2020 Published: October 9, 2020https://doi.org/10.18632/aging.103903
How to Cite
Copyright: © 2020 Rył et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
It has been suggested that visceral fat (VF) might be a negative determinant of bone health. The purpose of this cross-sectional study was to assess an interplay among fat, visceral fat (VF), muscle mass, bone mineral density (BMD), and markers of bone turnover in men aged 60-75 years. BMD, lean mass, total fat, VF and appendicular skeletal muscle mass (ASM) were assessed using dual-energy X-ray absorptiometry. Using ELISA assays, we measured serum levels of markers of bone turnover (osteocalcin, parathyroid hormone, human procollagen I N-terminal peptide, and degradation products of C-terminal telopeptide of type I collagen). Mean values of bone markers were within normal range. VF was found not to be associated with BMD and bone turnover markers. ASM was inversely correlated with age, and positively with BMD and lean mass. In linear regression, ASM, VF, total fat, lean mass and body mass index were significant single predictors of BMD. However, after adjustment for age, all these associations were no longer significant. In conclusion, in contrast to some studies on postmenopausal women, in older non-diabetic men with normal lean mass and body fat VF was not associated with BMD and markers of bone formation and resorption.