Research Paper Advance Articles

Colon cancer combined with obesity indicates improved survival- research on relevant mechanism

Zhou Yang1, *, , Xiyi Wei2, *, , Yitong Pan3, *, , Zhijun Min1, , Jingyuan Xu1,4, , Bo Yu1,5, ,

  • 1 Department of General Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China
  • 2 Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210009, Jiangsu, China
  • 3 Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, Nanjing 211116, China
  • 4 Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China
  • 5 Department of General Surgery, Huashan Hospital Affiliated to Fudan University, Shanghai 201399, China
* Equal contribution

Received: April 23, 2020       Accepted: July 30, 2020       Published: November 10, 2020      

https://doi.org/10.18632/aging.103972
How to Cite

Copyright: © 2020 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Obesity contributes to the incidence of various tumors, including colon cancer. However, the impact of obesity on patients’ survival and related mechanisms remains unclear. Multi-omics data of 227 cases of colon cancer patients combined with clinical characteristics data were acquired from The Cancer Genome Atlas (TCGA) database. We confirmed obesity as an independent prognostic factor for improved overall survival of colon cancer patients. We demonstrated that hypoxia pathways were repressed in obese patients by regulating miR-210. Immune checkpoints PD-1 and LAG3 were also downregulated in obese patients, which indicated enhanced immune surveillance. The frequency of PIK3CA and KRAS mutations was decreased in obese patients. The sites and types of TP53 mutation were alternated in obesity patients. In conclusion, our research demonstrated the potential mechanisms of prolonged survival in colon cancer patients combined with obesity, which may provide potential value for improving the prognosis of colon cancer.

Abbreviations

BMI: Body Mass Index; TCGA: The Cancer Genome Atlas; RPPR: Reverse Phase Protein Arrays; MAF: mutation annotation format; GO: Gene ontology; PPI: Protein–protein interaction; OS: Overall Survival; DFS: Disease-Free Survival; PFS: Progression-Free Survival; DEGs: Differentially expressed genes; DEMs: Differentially expressed miRNA; γδT: gamma delta T cell; CNV: Copy number variation.