Research Paper Volume 12, Issue 20 pp 20915—20923

Association of polymorphisms in ADAMTS-7 gene with the susceptibility to coronary artery disease - a systematic review and meta-analysis

Davood K. Hosseini1,2, *, , Sharareh Ataikia3, *, , Hanieh K. Hosseini1, *, , Baoai Han4, *, , Haiying Sun2,5, ,

  • 1 Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
  • 2 Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
  • 3 Shahid Beheshti University School of Medicine, Tehran, Iran
  • 4 Department of Public Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China
  • 5 Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
* Equal contribution

Received: July 23, 2020       Accepted: September 9, 2020       Published: October 29, 2020
How to Cite

Copyright: © 2020 Hosseini et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: To systematically review literature evidence to discover the association of ADAMTS7 (A Disintegrin And Metalloproteinase with Thrombospondin-like motifs 7) polymorphisms and the risk of developing CAD (coronary artery disease).

Data sources: A related literature search in online databases, including EMBASE, PubMed, and Web of Science was undertaken. The period covered was from 2007 to September 10, 2019.

Results: Of 256 citations retrieved, nine relevant studies were selected for detailed evaluation. Five SNPs (rs3825807, rs1994016, rs4380028, rs79265682, and rs28455815) in ADAMTS7 gene were identified among included studies. There were 51,851 cases and 89,998 controls included in four studies for SNP rs3825807, 13,403 cases and 11,381 controls included in two studies for SNP rs1994016, 37,838 cases and 38,245 controls included in two studies for SNP rs4380028, 3,133 cases and 5,423 controls included in one study for SNP rs79265682, 103,494 cases and 198,684 controls included in one study for SNP rs28455815. We found most consistent evidence for an association with CAD on coronary angiogram with ADAMTS7 SNP rs3825807 risk allele A in contrast to control G allele, followed by rs4380028 (C vs. T allele), and rs1994016 (C vs. T allele).

Conclusions: ADAMTS7 polymorphism is likely an important risk factor for development of CAD. Our data also suggest that the ADAMTS7 polymorphism may be a risk factor for CAD progression in patients who already have pathology in their coronary arteries.

Review methods: We included all studies in English language that reported correlation between the ADAMTS7 polymorphism and CAD in human cases.


ADAMTS7: A Disintegrin And Metalloproteinase with Thrombospondin-like motifs 7; ACAD: coronary artery disease; CI: confidence interval; GWAS: Genome-Wide Association Studies; HR: hazardous ratio; HWE: Hardy-Weinberg equilibrium; NOS: Newcastle-Ottawa scale; OR: odds ratio; SE: standard error; SNP: single nucleotide polymorphism.