Research Paper Volume 13, Issue 1 pp 301—339

KIAA0101 as a new diagnostic and prognostic marker, and its correlation with gene regulatory networks and immune infiltrates in lung adenocarcinoma

Sheng Hu1, , Weibiao Zeng1, , Wenxiong Zhang1, , Jianjun Xu1, , Dongliang Yu1, , Jinhua Peng1, , Yiping Wei1, ,

  • 1 Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China

Received: June 25, 2020       Accepted: September 22, 2020       Published: November 20, 2020
How to Cite

Copyright: © 2020 Hu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Proliferating cell nuclear antigen binding factor (encoded by KIAA0101/ PCLAF) regulates DNA synthesis and cell cycle progression; however, whether the level of KIAA0101 mRNA in lung adenocarcinoma is related to prognosis and tumor immune infiltration is unknown. In patients with lung adenocarcinoma, the differential expression of KIAA0101 was analyzed using the Oncomine, GEPIA, and Ualcan databases. The prognosis of patients with different KIAA0101 expression levels was evaluated using databases such as Prognostan and GEPIA. Tumor immune infiltration associated with KIAA0101 was analyzed using TISIDB. Linkedmics was used to perform gene set enrichment analysis of KIAA0101. KIAA0101 expression in lung adenocarcinoma tissues was higher than that in normal lung tissues. Patients with lung adenocarcinoma with low KIAA0101 expression had a better prognosis than those with high KIAA0101 expression. We constructed the gene regulatory network of KIAA0101 in lung adenocarcinoma. KIAA0101 appeared to play an important role in the regulation of tumor immune infiltration and targeted therapy in lung adenocarcinoma. Thus, KIAA0101 mRNA levels correlated with the diagnosis, prognosis, immune infiltration, and targeted therapy in lung adenocarcinoma. These results provide new directions to develop diagnostic criteria, prognostic evaluation, immunotherapy, and targeted therapy for lung adenocarcinoma.


KIAA0101/PCLAF: proliferating cell nuclear antigen binding factor; PCNA: proliferating cell nuclear antigen; LUAD: lung adenocarcinoma; GEO: Gene Expression Omnibus.