Research Paper Advance Articles pp 23548—23577
PsychoAge and SubjAge: development of deep markers of psychological and subjective age using artificial intelligence
- 1 Deep Longevity, Inc, Three Exchange Square, The Landmark, Hong Kong, China
- 2 Insilico Medicine, Hong Kong Science and Technology Park (HKSTP), Hong Kong, China
- 3 The Buck Institute for Research on Aging, Novato, CA 94945, USA
- 4 Singularity University, Mountain View, CA 94040, USA
Received: October 14, 2020 Accepted: November 24, 2020 Published: December 8, 2020https://doi.org/10.18632/aging.202344
How to Cite
Copyright: © 2020 Zhavoronkov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aging clocks that accurately predict human age based on various biodata types are among the most important recent advances in biogerontology. Since 2016 multiple deep learning solutions have been created to interpret facial photos, omics data, and clinical blood parameters in the context of aging. Some of them have been patented to be used in commercial settings. However, psychological changes occurring throughout the human lifespan have been overlooked in the field of “deep aging clocks”.
In this paper, we present two deep learning predictors trained on social and behavioral data from Midlife in the United States (MIDUS) study: (a) PsychoAge, which predicts chronological age, and (b) SubjAge, which describes personal aging rate perception. Using 50 distinct features from the MIDUS dataset these models have achieved a mean absolute error of 6.7 years for chronological age and 7.3 years for subjective age. We also show that both PsychoAge and SubjAge are predictive of all-cause mortality risk, with SubjAge being a more significant risk factor.
Both clocks contain actionable features that can be modified using social and behavioral interventions, which enables a variety of aging-related psychology experiment designs. The features used in these clocks are interpretable by human experts and may prove to be useful in shifting personal perception of aging towards a mindset that promotes productive and healthy behaviors.