Research Perspective Volume 13, Issue 3 pp 3167—3175
DNA- and telomere-damage does not limit lifespan: evidence from rapamycin
- 1 Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Received: January 29, 2021 Accepted: February 10, 2021 Published: February 12, 2021https://doi.org/10.18632/aging.202674
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Copyright: © 2021 Blagosklonny. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Failure of rapamycin to extend lifespan in DNA repair mutant and telomerase-knockout mice, while extending lifespan in normal mice, indicates that neither DNA damage nor telomere shortening limits normal lifespan or causes normal aging.