Research Paper Volume 13, Issue 12 pp 16733—16748
Gut microbiota mediates cognitive impairment in young mice after multiple neonatal exposures to sevoflurane
- 1 Department of Anesthesiology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
- 2 Department of Anesthesiology, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, China
- 3 Medical School of Soochow University, Suzhou, Jiangsu, China
- 4 Joint International Research Laboratory of Agriculture and Agri-Product Safety, Ministry of Education of China, Yangzhou University, Yangzhou, Jiangsu, China
Received: January 5, 2021 Accepted: May 31, 2021 Published: June 28, 2021https://doi.org/10.18632/aging.203193
How to Cite
Copyright: © 2021 Liu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Multiple exposures to anesthesia may increase the risk of cognitive impairment in young children. However, the mechanisms underlying this neurodevelopmental disorder remain elusive. In this study, we investigated alteration of the gut microbiota after multiple neonatal exposures to the anesthetic sevoflurane and the potential role of microbiota alteration on cognitive impairment using a young mice model. Multiple neonatal sevoflurane exposures resulted in obvious cognitive impairment symptoms and altered gut microbiota composition. Fecal transplantation experiments confirmed that alteration of the microbiota was responsible for the cognitive disorders in young mice. Microbiota profiling analysis identified microbial taxa that showed consistent differential abundance before and after fecal microbiota transplantation. Several of the differentially abundant taxa are associated with memory and/or health of the host, such as species of Streptococcus, Lachnospiraceae, and Pseudoflavonifractor. The results reveal that abnormal composition of the gut microbiota is a risk factor for cognitive impairment in young mice after multiple neonatal exposures to sevoflurane and provide insight into a potential therapeutic strategy for sevoflurane-related neurotoxicity.