| Aging

Copyright: © 2021 Tang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

This article has been corrected: The authors requested to correct the unit of cell number in Table 1 and Table 2 to μl instead of ml. This mistake was due to the font corruption. The authors declare that these corrections do not change the results or conclusions of this work.

The corrected Tables are posted below.

Table 1. Reference ranges of lymphocyte number, function, and phenotype in different age groups.

Parameters

All

Children

Adolescents

Adults

Elders

N=261

N=47

N=72

N=90

N=52

Age

Mean±SD
(Range)

33.68±26.63
(1-82)

3.81±1.04
(1-5)

10.81±3.74
(6-18)

46±13.79
(18-65)

71.04±4.39
(66-82)

Sex

Male:Female

168:93

35:12

52:20

53:37

28:24

Number

CD4⁺ T cell number (/μl)

Mean±SD
(2.5%-97.5%)

836±355
(374-1881)

1260±399
(635-1979)

927±287
(560-1653)

648±203
(360-1074)

652±187
(367-1007)

<0.001

CD8⁺T cell number (/μl)

Mean±SD
(2.5%-97.5%)

576±310
(154-1459)

880±343
(426-1553)

728±262
(397-1382)

424±171
(180-847)

355±154
(116-681)

<0.001

B cell number (/μl)

Mean±SD
(2.5%-97.5%)

358±252
(73-1006)

695±251
(251-1240)

457±173
(218-905)

184±81
(53-352)

216±140
(67-537)

<0.001

NK cell number (/μl)

Mean±SD
(2.5%-97.5%)

383±219
(103-920)

381±243
(89-905)

345±228
(86-934)

364±165
(154-732)

473±239
(125-1000)

<0.05

Function

IFN-g⁺CD4⁺ T cells (%)

Mean±SD
(2.5%-97.5%)

17.84±8.85
(6.62-36.81)

10.23±4.16
(4.08-17.17)

12.28±4.86
(5.43-20.35)

23.72±8.12
(12.34-40.53)

22.26±7.52
(8.83-34.43)

<0.001

IFN-g⁺CD8⁺ T cells (%)

Mean±SD
(2.5%-97.5%)

46.25±22.43
(13.59-87.72)

26.89±10.77
(8.95-46.18)

29.13±10.83
(13.63-56.57)

56.08±17.92
(22.76-87.38)

70.46±14.33
(42.84-92.36)

<0.001

IFN-g⁺ NK cells (%)

Mean±SD
(2.5%-97.5%)

72.68±12.65
(43.88-90.94)

67.28±14.57
(40.76-85.99)

67.77±13.16
(39.70-87.66)

77.29±9.95
(57.73-91.48)

76.37±9.52
(59.79-90.61)

<0.001

Phenotype

CD28⁺CD4⁺ T cells (%)

Mean±SD
(2.5%-97.5%)

94.95±7.03
(73.33-99.97)

98.17±4.03
(89.50-99.98)

97.92±2.72
(88.95-99.95)

92.81±7.6
(71.81-99.88)

91.61±9.10
(66.26-99.83)

<0.001

HLA-DR⁺CD4⁺ T cells (%)

Mean±SD
(2.5%-97.5%)

14.33±7.45
(5.42-32.78)

9.68±4.79
(5.29-24.40)

10.64±4.15
(5.11-19.71)

16.23±7.02
(5.97-34.34)

20.35±8.25
(9.07-40.22)

<0.001

CD45RO+CD4⁺T cells (%)

Mean±SD
(2.5%-97.5%)

50.89±18.88
(20.58-88.47)

28.77±7.71
(13.63-43.39)

40.37±9.88
(22.48-58.08)

61.09±14
(36.21-88.06)

67.82±14.07
(37.46-93.85)

<0.001

CD28⁺CD8⁺ T cells (%)

Mean±SD
(2.5%-97.5%)

62.06±17.3
(26.41-88.91)

71.58±12.49
(52.47-91.71)

71.39±12.36
(45.28-88.65)

58±15.87
(26.72-84.13)

47.57±16.5
(20.60-82.40)

<0.001

HLA-DR⁺CD8⁺ T cells (%)

Mean±SD
(2.5%-97.5%)

34.93±17.12
(9.97-71.53)

23.26±11.82
(7.42-47.14)

25.13±10.45
(9.98-46.31)

39.09±15.71
(14.96-72.95)

51.83±13.98
(22.97-74.98)

<0.001

SD: standard deviation. P means association between different parameters and age in all participants by using Spearman's rank correlation test.

Table 2. Reference ranges of calculated parameters in different age groups.

Parameters

All

Children

Adolescents

Adults

Elders

N=261

N=47

N=72

N=90

N=52

Age

Mean±SD
(Range)

33.68±26.63
(1-82)

3.81±1.04
(1-5)

10.81±3.74
(6-18)

46±13.79
(18-65)

71.04±4.39
(66-82)

CD4⁺ T cell number × function (/μl)

Mean±SD
(2.5%-97.5%)

134±66
(56-293)

125±58
(57-225)

108±40
(57-209)

153±75
(61-328)

147±73
(44-311)

<0.001

CD8⁺ T cell number × function (/μl)

Mean±SD
(2.5%-97.5%)

237±139
(72-567)

240±143
(65-565)

212±126
(86-489)

242±143
(79-564)

259±74
(67-553)

<0.05

NK cell number × function (/μl)

Mean±SD
(2.5%-97.5%)

283±175
(49-736)

254±157
(37-585)

241±184
(44-780)

286±142
(90-674)

216±125
(80-832)

<0.001

CD4⁺ T cell number × CD28⁺CD4⁺ T cells % (/μl)

Mean±SD
(2.5%-97.5%)

798±359
(333-1844)

1236±392
(631-1925)

909±288
(536-1638)

600±190
(318-1001)

594±173
(320-894)

<0.001

CD4⁺ T cell number × HLA-DR⁺CD4⁺ T cells % (/μl)

Mean±SD
(2.5%-97.5%)

110±60
(36-257)

121±70
(43-299)

95±37
(44-176)

103±52
(35-232)

135±78
(47-339)

<0.01

CD4⁺ T cell number × CD45RO⁺CD4⁺ T cells % (/μl)

Mean±SD
(2.5%-97.5%)

385±140
(192-709)

347±109
(220-557)

358±94
(225-570)

393±153
(165-735)

444±168
(219-748)

<0.001

CD8⁺ T cell number × CD28⁺CD8⁺ T cells % (/μl)

Mean±SD
(2.5%-97.5%)

364±232
(82-949)

618±233
(243-1011)

508±174
(262-950)

236±98
(104-435)

134±50
(57-286)

<0.001

CD8⁺ T cell number × HLA-DR⁺CD8⁺ T cells % (/μl)

Mean±SD
(2.5%-97.5%)

187±129
(41-547)

221±183
(38-565)

185±113
(67-452)

169±110
(39-478)

132±48
(46-436)

>0.05

SD: standard deviation. P means association between different parameters and age in all participants by using Spearman's rank correlation test.

Correction Volume 13, Issue 15 pp 19942—19944

Correction for: Establishing immune scoring model based on combination of the number, function, and phenotype of lymphocytes

Guoxing Tang^1, , Xu Yuan^1, , Ying Luo^1, , Qun Lin^1, , Zhishui Chen^2,3, , Xue Xing^4, , Huijuan Song^1, , Shiji Wu^1, , Hongyan Hou^1, , Jing Yu^5, , Liyan Mao^6, , Weiyong Liu^1, , Feng Wang^1, , Ziyong Sun^1, ,

Received: August 3, 2021 Accepted: August 9, 2021 Published: August 11, 2021

Table 1. Reference ranges of lymphocyte number, function, and phenotype in different age groups.

Table 2. Reference ranges of calculated parameters in different age groups.

Corresponding Authors

Keywords

Correction Volume 13, Issue 15 pp 19942—19944

Correction for: Establishing immune scoring model based on combination of the number, function, and phenotype of lymphocytes

Guoxing Tang1, , Xu Yuan1, , Ying Luo1, , Qun Lin1, , Zhishui Chen2,3, , Xue Xing4, , Huijuan Song1, , Shiji Wu1, , Hongyan Hou1, , Jing Yu5, , Liyan Mao6, , Weiyong Liu1, , Feng Wang1, , Ziyong Sun1, ,

Received: August 3, 2021 Accepted: August 9, 2021 Published: August 11, 2021

Table 1. Reference ranges of lymphocyte number, function, and phenotype in different age groups.

Table 2. Reference ranges of calculated parameters in different age groups.

Corresponding Authors

Keywords

Guoxing Tang^1, , Xu Yuan^1, , Ying Luo^1, , Qun Lin^1, , Zhishui Chen^2,3, , Xue Xing^4, , Huijuan Song^1, , Shiji Wu^1, , Hongyan Hou^1, , Jing Yu^5, , Liyan Mao^6, , Weiyong Liu^1, , Feng Wang^1, , Ziyong Sun^1, ,