COVID-19 Research Paper Volume 13, Issue 17 pp 20896—20905
Prognostic value of neutrophil-to-lymphocyte ratio, lactate dehydrogenase, D-dimer, and computed tomography score in patients with coronavirus disease 2019
- 1 Department of Clinical Medicine, Fujian Medical University, Fujian, China
- 2 Department of Pulmonary and Critical Care Medicine, Zhongshan Hospital, Xiamen University, Teaching Hospital of Fujian Medical University, Fujian, China
- 3 Department of Pulmonary and Critical Care Medicine, Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fujian, China
- 4 Department of Gastroenterology, Optic Valley Division of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 5 Department of Geriatrics, Zhongshan Hospital, Xiamen University, Teaching Hospital of Fujian Medical University, Fujian, China
- 6 Yichang Third People's Hospital, Third People's Hospital Affiliated to Sanxia University, Hubei, China
- 7 Department of Pulmonary and Critical Care Medicine, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China
Received: January 25, 2021 Accepted: August 24, 2021 Published: September 8, 2021https://doi.org/10.18632/aging.203501
How to Cite
Copyright: © 2021 Cai et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: This study aimed to explore the significance of neutrophil-to-lymphocyte ratio (NLR), lactate dehydrogenase (LDH), D-dimer, and CT score in evaluating the severity and prognosis of coronavirus disease 2019 (COVID-19).
Methods: Patients with laboratory-confirmed COVID-19 were retrospectively enrolled. The baseline data, laboratory findings, chest computed tomography (CT) results evaluated by CT score on admission, and clinical outcomes were collected and compared. Logistic regression was used to assess the independent relationship between the baseline level of the four indicators (NLR, LDH, D-dimer, and CT score) and the severity of COVID-19.
Results: Among the 432 patients, 125 (28.94%) and 307 (71.06%) were placed in the severe and non-severe groups, respectively. As per the multivariate logistic regression, high levels of NLR and LDH were independent predictors of severe COVID-19 (OR=2.163; 95% CI=1.162-4.026; p=0.015 for NLR>3.82; OR=2.298; 95% CI=1.327-3.979; p=0.003 for LDH>246 U/L). Combined NLR>3.82 and LDH>246 U/L increased the sensitivity of diagnosis in patients with severe disease (NLR>3.82 [50.40%] vs. combined diagnosis [72.80%]; p=0.0007; LDH>246 [59.2%] vs. combined diagnosis [72.80%]; p<0.0001).
Conclusions: High levels of serum NLR and LDH have potential value in the early identification of patients with severe COVID-19. Moreover, the combination of LDH and NLR can improve the sensitivity of diagnosis.