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Research Paper

LncRNA SNHG7 governs malignant phenotypes of cervical cancer cells via miR-122-5p/FOXP1 axis

Yanmei Hou1, Hui Liu2, Min Song3, Xiaohong Yu4, Jie Li5, Junli Lu6, Meng Xu7
  • 1Department of Gynecology, Jinan Maternity and Child Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China
  • 2Reproductive Medicine Department, People’s Hospital of Rizhao, Rizhao, Shandong Province, China
  • 3Department of Gynaecology and Obstetrics, Jinan Maternal and Child Health Hospital, Jinan, Shandong Province, China
  • 4Department of Urology Surgery, Linyi People’s Hospital, Linyi, Shandong Province, China
  • 5Outpatient Service of Department of Gynaecology, Jinan Second Maternal and Child Health Hospital, Jinan, Shandong Province, China
  • 6Infection Control Department, Qingdao Chengyang District People’s Hospital, Qingdao, Shandong Province, China
  • 7Department of Ultrasound, Jinan Maternal and Child Health Hospital, Jinan, Shandong Province, China
Received: April 13, 2021Accepted: July 15, 2021
https://doi.org/10.18632/aging.

Copyright: © 2021 Hou et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cervical cancer is one of the most common malignancies in the female population. Long non-coding RNA small nucleolar RNA host gene 7 (lncRNA SNHG7) has been reported to be an oncogene. In the current study, we aimed to investigate the effects of lncRNA SNHG7 on malignant phenotypes of cervical cancer cells. Firstly, upregulation of lncRNA SNHG7 and downregulation of microRNA-122-5p (miR-122-5p) were found in cervical cancer, and lncRNA SNHG7 augmented resistance to cisplatin and promoted proliferative, migratory and invasive capacities of cervical cancer cells. Moreover, we found miR-122-5p functioned as the downstream molecule of lncRNA SNHG7 to inhibit the effects of lncRNA SNHG7 on malignant phenotypes of cervical cancer cells. Further investigation revealed that miR-122-5p directly targeted forkhead box p1 (FOXP1), and FOXP1 overexpression reversed lncRNA SNHG7 knockdown-attenuated chemoresistance and proliferative, migratory and invasive capacities of cervical cancer cells. The in vivo experiment indicated lncRNA SNHG7 knockdown suppressed growth of cervical cancer. Taken together, our research uncovered lncRNA SNHG7/miR-122-5p/FOXP1 axis boosted malignant phenotypes of cervical cancer, highlighting an alternative mechanism contributing to pathogenesis of cervical cancer.