Research Paper Volume 13, Issue 21 pp 24236—24250
The first central precocious puberty proteomic profiles revealed multiple metabolic networks and novel key disease-associated proteins
- 1 Department of Pediatrics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China
- 2 Hailiang Hospital, Zhuji, Zhejiang Province, China
- 3 College of Life Science, Zhejiang University, Hangzhou, Zhejiang Province, China
Received: September 7, 2021 Accepted: October 28, 2021 Published: November 8, 2021https://doi.org/10.18632/aging.203676
How to Cite
Copyright: © 2021 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Though central precocious puberty (CPP) as a disease that seriously affects the development of a child is increasing year by year, treatment options remain limited and is the same as the 1980s’ method. These are mainly due to the complex pathogenesis of central precocious puberty. Therefore, systems biology approach to identify and explore the multiple factors related to the pathogenesis of central precocious puberty is necessary. Our data established the first proteome profile of CPP revealed 163 down-regulated and 129 were up-regulated differentially expressed proteins. These altered proteins were primarily enriched in three metabolic process including energy metabolism, amino acid metabolism and nitrogenous base metabolism. The identified altered members of the metabolic signaling are valuable and potential novel therapeutic targets of central precocious puberty.