Research Paper Volume 14, Issue 2 pp 770—779

Impact of marital status on survival in patients with stage 1A NSCLC

Liu Huang1, *, , Shu Peng2, *, , Chenyu Sun3, , Lian Chen1, , Qian Chu1, , Sudip Thapa1, , Vanisha Chummun4, , Lu Zhang1, , Peng Zhang1, , Eric L. Chen3, , Ce Cheng5, , Yuan Chen1, ,

  • 1 Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R. China
  • 2 Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, P.R. China
  • 3 AMITA Health Saint Joseph Hospital Chicago, Chicago, IL 60657, USA
  • 4 Department of Radiotherapy and Oncology, Victoria Hospital, Candos, Quatre Bornes 72259, Mauritius
  • 5 The University of Arizona College of Medicine at South Campus, Tucson, AZ 85713, USA
* Equal contribution

Received: November 17, 2020       Accepted: September 18, 2021       Published: January 19, 2022
How to Cite

Copyright: © 2022 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objectives: To study how marital status influences overall survival (OS) in patients with stage IA non-small cell lung cancer (NSCLC). And whether the result is valid in different time periods.

Materials and Methods: We retrospectively analyzed 55,207 cases of stage IA NSCLC from 1995 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) database. Marital status was classified as follows: married or with unmarried/domestic partner (MR/W.P), divorced or separated (DV/SP), widowed (WD), and single (never married). Patients diagnosed in 1995-2005 and 2006-2015 were analyzed separately as groups 1 and 2, respectively, to validate the results. Within each group, age-stratified demographic, clinicopathologic features, and OS were compared among different marital statuses.

Results and Conclusions: A total of 55,207 cases were included (group 1 n=20,223, group 2 n=34,984). From 1995-2005 to 2006-2015, median OS was prolonged significantly in all patients besides the DV/SP subgroup. In general, being MR/W.P was associated with the lowest relative risk of death in the study population (Group 1, HR= 0.854, 95%CI: 0.816-0.893; Group 2, HR = 0.799, 95%CI: 0.758-0.842). Meanwhile, OS of DV/SP and widowed patients was similar. In group 2, being single was associated with lower risk of death beyond 60-year-old.


OS: Overall survival; NSCLC: Non-small cell lung cancer; SEER database: Surveillance, Epidemiology, and End Results database; MR/W.P: Married or with unmarried/domestic partner; DV/SP: Divorced or separated; WD: Widowed; SG: Single (never married).