Review Volume 1, Issue 1 pp 28—37

Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

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Figure 1. Maturation of lamin A and formation of progerin or LA∆50. (A) Normal processing of prelamin A. (B) Processing of G608G mutation (C1824T) in HGPS cells. Underline LY (in black) in the deleted 50 AAs: Zmpste24 cleavage site