Review Volume 3, Issue 9 pp 829—835

Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair

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Figure 1. The second wave of SIRT6 recruitment to DSBs is concomitant with global deacetylation of H3K9. Human fibroblasts were exposed to γ-irradiation. Immunoblotting revealed that H3K9-Ac levels are reduced 8 hours following irradiation, concurrent with a second wave of SIRT6 recruitment to DSBs.