Research Paper Volume 3, Issue 12 pp 1169—1177

Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass

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Figure 3. Chronic Oxt infusion decreases body weight, food intake and visceral fat mass. (A, B) Body weight gain (A) and daily food intake (B) after implantation of Oxt (1,600 μg/kg/day) infusion minipump. (C) Cumulative food intake for day 1 through day 6 is calculated from Fig. 3B. (D-G) Wet weights (D) and relative areas (E) of mesenteric fat in control and Oxt infused mice. Microphotographs of mesenteric fat in control (F) and Oxt infused (G) mice. (H-K) Wet weights (H) and relative areas (I) of epididymal fat in control and Oxt treated mice. Microphotographs of epididymal fat in control (J) and Oxt treated (K) mice. Relative areas of adipocytes were calculated from histological section in mesenteric and epididyamal fat. (L-M) Wet weights of liver in control and Oxt treated (L) mice. Microphotographs of control (M) and Oxt infused (N) mice. Scale bars in all photomicrographs indicate 50 μm. *p < 0.05, **p < 0.01.