Research Paper Volume 6, Issue 1 pp 48—57

Figure 5. Expression of mtor and deptor is deregulated in the liver of Bmal1^−/− mice. The expressions of several components of TORC1 and upstream regulator of TORC1 in the liver of wild type and Bmal1^−/− mice were analyzed across the daily cycle on mRNAs level by real-time RT PCR. All expression data were normalized to 18S ribosomal RNA expression. (a-c) Expression of mRNAs for tor (a), deptor (b), rheb (c) in the liver of TRF WT (black diamonds) or Bmal1^−/− (grey squares) mice. Results represent average for 4 animals of each genotype for each time point.* - statistically significant difference between the genotypes. Bars on the top of the figure represent light (open bars) and dark (black bars) parts of the day.