Research Paper Volume 6, Issue 8 pp 621—644

D-beta-hydroxybutyrate extends lifespan in C. elegans

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Figure 3. D-βHB dehydrogenase activity in worm extracts following RNAi-mediated gene knockdown. (A) D-βHB dehydrogenase activity following worm culture in the absence or presence of 10 mM D-βHB. Conditions in the legend refer to the culture conditions. The genes F55E10.6, dhs-2, dhs-16, or dhs-20 were knocked down by RNAi feeding (* p < 0.05 compared to Control + 10 mM D-βHB; # p < 0.05 compared to Control). (B) D-βHB dehydrogenase activity following worm culture in the absence or presence of 10 mM L-βHB. The assay conditions were the same as panel A (# p < 0.05 compared to Control).