Research Paper Volume 7, Issue 12 pp 1112—1128

RPD3 histone deacetylase and nutrition have distinct but interacting effects on Drosophila longevity

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Figure 1. Longevity of rpd3 heterozygous mutant flies. (A) Survivorship curves of male and female rpd3def/+ and +/+ control flies on 1.0N (A) and corn food (B). Male rpd3def/+ flies have increased mean and maximal longevity on both food levels compared to controls. Female rpd3def/+ flies have maximal longevity increased on both food levels but mean is increased on 1.0N. (C) Mean longevity of rpd3def/+ and +/+ control flies, male and female, on food levels ranging from 0.5N to 1.5N. (D) Mean longevity of rpd3P-UTR/+ and rpd3P-1.8/+ control flies, male and female, on food levels ranging from 0.3N to 1.5N. (E, F) Survivorship of male (E) and female (F) rpd3P-UTR/+ and rpd3P-1.8/+ controls, on 0.1N food. See Tables 14 for number of flies in each experiment and statistical analysis.