Review Volume 8, Issue 4 pp 603—619

Apoptosis as anticancer mechanism: function and dysfunction of its modulators and targeted therapeutic strategies

Figure 1. Intrinsic and extrinsic apoptotic pathways. The intrinsic (mitochondrial) and the extrinsic (ligands/death receptors) cell death pathways and their convergence through t-Bid are depicted (see text for details)