Research Paper Volume 8, Issue 6 pp 1259—1269

Growth differentiation factor 6 derived from mesenchymal stem/stromal cells reduces age-related functional deterioration in multiple tissues

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Figure 6. Lentiviral transduction of Gdf6 ameliorated age-related pathologies. (A) Representative FACS plots showing the percentages of B- (B220+), T- (CD3e+), and myeloid (CD11b+) cells in PB 16 weeks after transduction. (B) Embryonic myosin heavy chain+ (eMHC+) regenerating myoblasts and myotubes 5 days after CTX injury were examined by immunohistochemistry. Scale bar: 100 μm. (C) The number of Sox2+ neural progenitor cells was elevated in hGDF6-transduced mouse brains. Scale bars: 100 μm. (D) Relative plasma levels of inflammatory factors (n ≥ 4). Results are expressed as means ± SEM. *p < 0.05, **p < 0.01.