Research Paper Volume 8, Issue 9 pp 2232—2252

Global gene profiling of aging lungs in Atp8b1 mutant mice

class="figure-viewer-img"

Figure 2. Ingenuity Pathway Analysis (IPA) identified perturbation of cellular assembly, organization, function, and maintenance in aged network to be perturbed in aged C57BL/6 lungs. Some of the key molecules in this network are shown in the figure. The genes Col1a, Col3a1, Zbtb16 and Rgcc were downregulated , whereas Mkx and Lair were upregulated in aged C57BL/6 lungs.