Research Paper Volume 8, Issue 11 pp 2814—2826

Caloric restriction preserves memory and reduces anxiety of aging mice with early enhancement of neurovascular functions

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Figure 3. Caloric restriction decelerates the rate of decline of cerebral blood flow in aging mice. Old CR mice had significantly higher CBF in (A) Frontal cortex and (B) Hippocampus; however (C) P-gp activity did not show significance when compared with old AL mice. The age-dependent changes between AL and CR mice in (D) CBF within frontal cortex, and (E) hippocampus, and (F) Differnce in cortical P-gp activity, between AL and CR mice. Data are mean ± SEM. **p < 0.01; n.s.: non-significant; AL: ad libitum; CR: caloric restriction.