The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Jutaro Fukumoto; Ramani Soundararajan; Joseph Leung; Ruan Cox; Sanjay Mahendrasah; Neha Muthavarapu; Travis Herrin; Alexander Czachor; Lee C. Tan; Nima Hosseinian; Priyanshi Patel; Jayanthraj Gone; Mason T. Breitzig; Young Cho; Andrew J. Cooke; Lakshmi Galam; Venkata Ramireddy Narala; Yashwant Pathak; Richard F. Lockey; Narasaiah Kolliputi

doi:doi:10.18632/aging.101115

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Research Paper Volume 8, Issue 11 pp 3091—3109

The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis

Figure 6. A hypothesized model of club cell involvement in IPF pathogenesis. Black arrows denote putative reparative cascades by club cells. Red arrows denote our hypothesis regarding how club cell phenoconversion leads to the formation of fibroblastic foci (FF) in IPF development.