Research Paper Volume 10, Issue 4 pp 606—621

Sex differences in transcriptomic profiles in aged kidney cells of renin lineage

Figure 5. Differentially expressed genes (DEGs) and pathways in young female vs. young male. (A) Comparisons made included age with female and male-centric views. (B) Volcano plot showing up-regulated (mustard) and down-regulated (blue) DEGs, and those not significant (grey). Text boxes highlight individual genes discussed in results section. (C) Gene ontology (GO) terms significantly enriched in genes up-regulated in young female vs. young male mice. (D) GO terms significantly enriched in genes down-regulated in young female vs. young male mice. (E) Expression pattern of young female vs. young male DEGs across all age and sex conditions. Group A genes (43.4% of all DEGs) are decreased with age; Group B genes (56.6%) either persisted or increased with age.