Research Paper Volume 10, Issue 4 pp 632—644

KCNQ1OT1 promotes melanoma growth and metastasis

Figure 4. Overexpression of MET enhances transcription and lncRNA-coated territory of KCNQ1OT1. (A) Correlation between MET expression and KCNQ1OT1. (B, C) Fluorescence intensity was measured in HACAT cells co transfected with KCNQ1OT1, KCNQ1OT1 MUT or si-KCNQ1OT1, and MET WT/MUT construct. Vector was used as a control. (D, E) After transfecting KCNQ1OT1/control in A375 cells, MET level was detected by western blot and real time PCR. Data are shown as mean ± SEM. ** P< 0.01 (F, G) After transfecting si-KCNQ1OT1 or control in A375 cells, MET level was detected by western blot and real time PCR. Data are shown as mean ± SEM. ** P< 0.01.