Research Paper Volume 10, Issue 4 pp 701—746

Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue

Figure 7. Genes increased by CR in humans and Gene Ontology-based mouse comparison. (A) GO BP terms most strongly enriched among genes increased by CR across 28 human experiments. (B) Genes associated with blood vessel remodeling (GO:0001974). (C) Genes associated with stem cell population maintenance (GO:0019827). (D) Genes associated with biosynthetic process regulation (GO:0009889). (E) Genes associated with aging (GO:0007568). (F) Genes most strongly increased by CR in humans and mice. (G) Genes increased by CR in humans but decreased in mice. In (F) and (G), color-coded bars show average FC estimates in humans (top) and mice (bottom). Average FC estimates are listed within each figure. (H) GO BP terms enriched among 70 genes increased by CR in humans and mice. Genes were increased by 5% on average in humans (FDR < 0.10) and increased by CR with respect to at least 6 of 7 mouse strains (P < 0.05 per strain). (I) GO BP terms enriched among 115 genes increased by CR in humans but decreased by CR in mice. Genes were increased by 5% on average in humans (FDR < 0.10) and decreased by CR with respect to at least 6 of 7 mouse strains (P < 0.05 per strain). In (H) and (I), the number of genes associated with each GO BP term is listed in parentheses (left margin) and example genes are listed within the figure.