Research Paper Volume 10, Issue 6 pp 1223—1238

Inactivation of hepatic ATRX in Atrx Foxg1cre mice prevents reversal of aging-like phenotypes by thyroxine

Figure 2. Low subcutaneous fat or serum glucose are not rescued by T4 administration in Atrx Foxg1cre (cKO) mice. (a) H & E staining of P20 skin cryosections shows that subcutaneous fat (SF) is not restored to control levels in Atrx Foxg1cre mice following T4 treatment (n=3). Dermal layer (D) was unchanged between control and either PBS or T4 treated Atrx Foxg1cre mice as previously reported (Scale bar = 200 µm). (b) Serum glucose at P14 was not restored to control levels in Atrx Foxg1cre mice following T4 treatment. Groups with the same letter have means that are not significantly different. Groups with different letters have means that are significantly different (p<0.05). Error bars represent SEM.