Research Paper Volume 10, Issue 7 pp 1722—1744

Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling

Figure 7. HO-1 alleviated endothelial senescence through regulating phosphorylation status of eNOS at Ser1177 in SHRs. (A) Upregulation of HO-1 reduced blood pressure in the SHR. *P < 0.05 vs. WKY; #P < 0.05 vs. SHR. n = 6. (B) SA-β-gal staining of the aortas originated from WKYs, SHRs, and SHRs treated with Hemin. (C) Hemin attenuated the high expression of p53 in the SHR. *P < 0.05 vs. WKY; #P < 0.05 vs. SHR. n = 8. (D) Hemin increased the downregulation of p-eNOS (Ser1177) in SHRs, while had no effect on the expression of eNOS. *P < 0.05 vs. WKY; #P < 0.05 vs. SHR; n.s., non significant. n = 7-12.