Research Paper Volume 10, Issue 11 pp 3371—3381

LncRNA CDKN2BAS predicts poor prognosis in patients with hepatocellular carcinoma and promotes metastasis via the miR-153-5p/ARHGAP18 signaling axis

Figure 2. The effect of CDKN2BAS on HCC cell migration in vitro and in vivo. (A) The effect of CDKN2BAS on HCC cell migration was detected by Transwell migration assay; (B) The effect of overexpression or silencing of CDKN2BAS on HCCLM3 cell migration was detected by Scratch assay; (C) CDKN2BAS promoted the metastasis of HCCLM3 cells in nude mice. Left panel: representative images of lung metastasis were captured by bioluminescence imaging. Right panel: Luciferase signal intensities of nude mice 6 week after injection with HCCLM6/CDKN2BAS cells or control cells. (D) CDKN2BAS promoted the metastasis of MHCC97H cells in nude mice. Luciferase signal intensities of nude mice 6 week after injection with MHCC97H/CDKN2BAS cells or control cells. *P < 0.05, **P < 0.01.