Research Paper Volume 10, Issue 11 pp 3371—3381

LncRNA CDKN2BAS predicts poor prognosis in patients with hepatocellular carcinoma and promotes metastasis via the miR-153-5p/ARHGAP18 signaling axis

Figure 3. The effect of CDKN2BAS on HCC cell growth in vitro and in vivo. (A-B) The effect of overexpression or knockdown of CDKN2BAS on the growth of HCCLM3 cells was detected by MTT assay; (C-D) The effect of overexpression or knockdown of CDKN2BAS on the colony formation of HCCLM3 cells was detected by colony formation assay; (E-F) The effect of CDKN2BAS on EPI-induced apoptosis in HCCLM3 cells was detected by flow cytometry; (G) Tumor xenograft model in nude mice. CDKN2BAS-transfected HCCLM3 cells and control cells were inoculated to the right side of nude mice. (H-I) The tumor volume and tumor weight were analyzed. *P < 0.05, **P < 0.01, ***P < 0.001.