Research Paper Volume 10, Issue 12 pp 4141—4151

Naringin targets Zeb1 to suppress osteosarcoma cell proliferation and metastasis

Figure 1. Naringin inhibits the expression of Zeb1 in osteosarcoma cells. (A, B) Zeb1 expression in 30 human osteosarcoma specimens and their adjacent normal tissue counterparts was detected by Western blot and real-time PCR. **P < 0.05, vs normal tissues. (C, D) Zeb1 expression in MG63, U2OS and hFOB1.19 cells, detected by Western blot and real-time PCR. **P < 0.05, vs hFOB1.19 cells. (E-H) Zeb1 expression detected by Western blot and real-time PCR in MG63 and U2OS cells treated with NaCl or indicated concentrations of naringin for 24 h. **P < 0.05, compared with NaCl.