Research Paper Volume 11, Issue 1 pp 63—72

Mesenchymal stem cells rejuvenate cardiac muscle after ischemic injury

Figure 2. CD146+MSCs have a better protective effect on heart function than tMSCs in MI-mice. Four groups of mice were applied. Group 1, mice received sham surgery and injection of saline (Sham). Group 2, mice received MI surgery and injection of saline (MI). Group 3, mice received MI surgery and injection of tMSCs (MI+tMSCs). Group 4, mice received MI surgery and injection of CD164+MSCs (MI+CD164+MSCs). Four weeks later, the mouse heart function was assessed using ventricular catheterization. (A) End systolic pressure-volume relationship (ESPVR) (B) left ventricular end systolic pressure (LVESP) (C) Positive maximal pressure derivative (+dP/dt). (D-E) Masson's trichrome staining to determine the fibrotic heart tissue, shown by quantification (D), and by gross images (E). *p<0.05. N=10.