Research Paper Volume 11, Issue 1 pp 209—229

Oxidative stress induces club cell proliferation and pulmonary fibrosis in Atp8b1 mutant mice

Figure 3. Atp8b1G308V/G308V mice under hyperoxic conditions display patchy thickening of bronchiolar epithelium with epithelial hypercellularity. (A & B) Photomicrographs of H&E stained lung sections from WT and Atp8b1G308V/G308V mice exposed to 100% O2 for 48 hrs (n=3 for each). (C & D) Photomicrographs of TUNEL stained lung sections from WT and Atp8b1G308V/G308V mice exposed to 100% O2 for 48 hrs. Arrowheads denote thickened bronchiolar epithelium of hyperoxic Atp8b1G308V/G308V lungs. TUNEL positive cells are denoted by arrows. Br: Bronchiolar lumen. Magnifications: (A & B) 100X; (C & D) 200X. Data presented are representative of two independent experiments.