Figure 1. Loss of GPR109A induced significant weight gain without affecting food intake. (A) Body weight of WT and Gpr109a-/- mice was recorded weekly for a period of 12 months and (B) final body weight at the end of 12 months was calculated. (C) Visual appearance from a dorsal view of 12-month-old WT and Gpr109a-/- mouse shows significant differences in the body weight. (D) Food intake of WT and Gpr109a-/- mice was recorded weekly for a period of 12 months and (E) average food intake was calculated. Data are presented as mean ± S.E.M for (n=6). *p<0.05 vs. WT.