Research Paper Volume 11, Issue 2 pp 615—633

MiR-223-3p promotes cell proliferation and metastasis by downregulating SLC4A4 in clear cell renal cell carcinoma

Figure 2. MiR-223-3p promotes RCC cell proliferation, migration and invasion in vitro. MiR-223-3p levels were measured in (A) renal cancer tissue samples and (B) cell lines. The transfection effects of (C) miR-223-3p mimics and (D) miR-223-3p inhibitors were measured in 786-O and Caki-1 cells. The effects of (E) miR-223-3p mimics and (F) miR-223-3p inhibitors on cell proliferation were measured by the CCK-8 assay in 786-O and Caki-1 cells. Representative pictures display the (G) migration and (H) invasion of 786-O cells treated with miR-223-3p inhibitors. Data are shown as the mean ± SEM. * p < 0.05; ** p < 0.01; *** p < 0.001.