Research Paper Volume 11, Issue 4 pp 1089—1109

MALAT1/miR-15b-5p/MAPK1 mediates endothelial progenitor cells autophagy and affects coronary atherosclerotic heart disease via mTOR signaling pathway

Figure 9. AntgoMALAT1 protects mice against atherosclerosis. (A, B) The expression of MALAT1 was determined by qRT-PCR in plasma and aortic tissue from ApoE−/− +RCD and ApoE−/− +HFD mice which were injected with antagoMALAT1 or antagoNC, n=5. **P<0.01, compared with antagoNC group; ##P<0.01, compared with ApoE−/− +RCD group. (C) Western blot result of MAPK1, phosphorylated mTOR, mTOR and autophagy related protein ATG1 and LC3-II in ApoE−/− +RCD group. **P<0.01, compared with antagoNC group. (D) Western blot result of MAPK1, phosphorylated mTOR, mTOR and autophagy related protein ATG1 and LC3-II in ApoE−/− +HFD group. **P<0.01, compared with antagoNC group. (E) QRT-PCR results of VCAM-1/ICAM-1 expression with the different treatment in ApoE−/− +RCD and ApoE−/− +HFD groups. **P<0.01, compared with antagoNC group; ##P<0.01, compared with ApoE−/− +RCD group.