Research Paper Volume 11, Issue 2 pp 707—723

Age-related immune-modulating properties of seminal fluid that control the severity of asthma are gender specific

Figure 4. Enhanced transcription of osteopontin and IL-17A in lungs of asthmatic mature male mice. (A) Schematic representation of experimental design for asthma induction in mature male mice. Sensitized young adult male mice were challenged with ovalbumin (OVA) at 10 months of age. (B) Changes in Th2-cell-driven allergic responses in asthmatic mature male mice. White box: control group (n = 3); colored boxes: asthma groups (n = 5 - 7). (C) Representative images of PAS staining of lungs from asthmatic mature male mice. AW: airway. (D) Enhanced transcription of osteopontin and IL-17A in lungs of asthmatic mature male mice. White box: control group (n = 3); colored boxes: asthma groups (n = 5–7). Data are presented as means ± SEM. **P < 0.01 and *P < 0.05 versus young OVA asthma group.