Research Paper Volume 11, Issue 3 pp 898—907

p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis

Figure 6. Schematic of the study. while M1 macrophages participate into the adverse pathogenesis in EAE, p38MAPK/SGK1 signaling induces M2 macrophage polarization, which reduces the severity of EAE.