Research Paper Volume 11, Issue 3 pp 933—949

AluYb8 insertion polymorphism in the MUTYH gene impairs mitochondrial DNA maintenance and affects the age of onset of IPF

Figure 1. Relationship between the AluYb8MUTYH genotype and mtDNA state in the IPF patients and healthy controls. (A) The MT-ND1 content index was increased in the IPF patients, P<0.05. (B) The MT-ND1 content index of the P/P patients was significantly higher than that of the healthy controls with the same genotype, P<0.05. (C) Relative amplification of mtDNA in the IPF patients and healthy controls. (D) Relative amplification of nDNA in the IPF patients and healthy controls. (E) Relative amplification of nDNA in patients with different AluYb8MUTYH genotypes. (F) Relative amplification of mtDNA in patients with different AluYb8MUTYH genotypes. * A significant difference compared to P/P. # A significant difference compared to the healthy controls with the same genotype, P<0.05.