Research Paper Volume 11, Issue 3 pp 933ā€”949

AluYb8 insertion polymorphism in the MUTYH gene impairs mitochondrial DNA maintenance and affects the age of onset of IPF

Figure 2. The mRNA levels of mitochondrial genes and mitochondrial regulation-related genes in the IPF patients and healthy controls. (A) ATP6 and (B) COX2 mRNA expression in the IPF patients and healthy controls. (C) The ATP6 and COX2 expression levels in the patients and healthy controls with different AluYb8MUTYH genotypes. (Dā€“F) MFN2, POLG and ATG7 expression in the patients and healthy controls. (G) The MFN2, POLG and ATG7 mRNA levels among the IPF patients and healthy controls with different AluYb8MUTYH genotypes. * A significant difference between IPF patients with the A/P and P/P genotypes, P<0.05. # A significant difference between IPF patients with the A/A and A/P genotypes, P<0.05.