Research Perspective Volume 11, Issue 3 pp 1065—1068

Hallmarks of the cancer cell of origin: Comparisons with “energetic” cancer stem cells (e-CSCs)

Figure 3. Therapeutic targeting of e-CSCs. Experimentally, both an OXPHOS inhibitor (Diphenyleneiodonium; DPI) and a CDK4/6 (Ribociclib) inhibitor were effective in abrogating the 3D-propagation of e-CSCs.