Research Paper Volume 11, Issue 5 pp 1427—1439

FoxD2-AS1 promotes glioma progression by regulating miR-185-5P/HMGA2 axis and PI3K/AKT signaling pathway

Figure 3. FOXD2-AS1 regulates the proliferation, migration, and apoptosis of glioma cells by miR-185-5p. (A, B) Effects of FOXD2-AS1 and miR-185-5p on the proliferation of U251 and U87 cells were detected by MTT. (C-F) Effects of FOXD2-AS1 and miR-185-5p on the migration of U251 and U87 cells were detected by Transwell migration assay. *p < 0.05, **p < 0.01 vs. Control; #p < 0.05, ##p < 0.01 vs. NC; &P<0.05 vs si-FOXD2-AS1. (G, H) Effects of the FOXD2-AS1/miR-185-5p axis on the apoptotic rates of U251 and U87 cells were determined by flow cytometry. **p < 0.01 vs. Control; ##p < 0.01 vs. NC; &p < 0.05 vs. si-FOXD2-AS1.