Figure 2. The effect of age on circulating RAGE isoforms in male and female. cRAGE values were derived by subtracting esRAGE values from the total sRAGE. Bars represent serum levels of total sRAGE, cRAGE and esRAGE in the male and female of three age groups of a healthy population, young (≤45 yrs; male n=17, female n=18-19), middle age (46-64 yrs; male n=34-35, female n=32-37) and elderly-old (≥65 yrs; male n=23, female n=36-37). Values are expressed as median and interquartile range. *P < 0.05; **P < 0.01; ***P < 0.0001; Kruskal-Wallis with Dunn’s for multiple comparison test between age groups of the same gender; Mann Whitney test between male and female of the same age group.