Figure 1. Concentric and eccentric exercise induce a common transcriptomic response in young and older muscle. Overlap of contraction mode-associated differentially expressed genes within age groups. Near complete overlap exists between up-regulated (top left Venn) and down-regulated (top right Venn) genes, 5 h after concentric and eccentric exercise in young muscle. Up-regulated (bottom left Venn) and down-regulated (bottom right Venn) genes in older muscle after concentric and eccentric exercise also display predominant overlap.